English
What Are You Looking For?
Cordycepin from Cordyceps militaris: Precision-Bioactivity for Modern Health Solutions
Structural Superiority
Cordycepin (C??H??N?O?), a rare nucleoside analog, mimics adenosine yet resists degradation due to its 3’-deoxy structure. This enables unique bioactivity:
Source: Journal of Biological Chemistry 2023
Patented Purification Protocol
Our vertically integrated process ensures uncompromised quality:
Cultivation: Cordyceps militaris grown in controlled bioreactors (ISO 14644-1 Class 8)
Extraction: Supercritical CO? + UHPLC isolation (>98% purity)
Verification:
HPLC-ELSD/PDA: Quantification (1%-99% customizable)
LC-MS/MS: Confirms molecular identity (m/z 252.1 → 136.0)
NMR: Validates stereochemical purity (¹H/¹³C)
Impurity Control
Residual solvents: <10ppm (ICH Q3C compliant)
Heavy metals: <0.5ppm (Pb/Cd/As/Hg)
Cordycepin selectively accumulates in cancer cells via ENT1 transporters, inducing:
? Apoptosis: Caspase-3/7 activation (IC?? = 28μM in A549 cells)
? Metastasis Suppression: MMP-9 downregulation (72% inhibition at 50μM)
In vivo data: 57% tumor volume reduction vs. controls (Zebrafish xenograft model)
· Enhances NK cell activity by 230% (10mg/kg dose in murine models)
· Inhibits NLRP3 inflammasome → Reduces cytokine storms
· AMPK-mediated glucose uptake ↑ 300% (L6 myotubes)
· ATP regeneration ↑ 45% in exhaustive exercise models
Challenge: Cordycepin degrades rapidly in heat/pH >7.0
Our Solution:
Nano-Encapsulation: Chitosan coating extends half-life by 5x
Storage Protocol:
Formulation Guidance: Compatible with enteric coatings, lipid carriers
| Parameter | Specification |
|---|---|
| Purity (HPLC-ELSD) | 1%, 3%, 5%, 7%, 21%, 50%, 98%+ |
| Appearance | White cryst. (≥98%) / Brown pow. (<50%) |
| Solubility | DMSO >100mg/ml; Water <1mg/ml |
| Bioactivity | AMPK EC?? = 0.8μM |
| Sector | Formula Integration | Mechanistic Role |
|---|---|---|
| Pharma Intermediates | Oncolytic drug conjugates | Telomerase inhibitor |
| Nutraceuticals | Sublingual tablets / Sports gels | ATP booster + Anti-fatigue |
| Cosmeceuticals | Acne serums (0.5-2%) | Anti-inflammatory / Sebum control |
| Animal Health | Poultry feed additive (100ppm) | Antibiotic alternative |
? Batch-to-Batch Consistency
RSD <2.0% for 98% purity grade (n=20 batches)
? Scalable & Compliant
· GMP-aligned facility (Weifang Huazhi subsidiary)
· Kosher/Halal/ISO 9001 certifications
? Research-Ready Support
· Free cell-based assay data (e.g., IC?? on 12 lines)
· Custom molecular docking studies
Download Resources:
[? Cordycepin Mechanism of Action Dossier] • [? HPLC/MS Spectral Library]
Science you can formulate with. Nature you can trust.
Precision: UHPLC isolation eliminates psoralen-like contaminants
Potency: 3D cell-validated bioactivity (vs. 2D industry standard)
Partnership: Co-development of cordycepin-derivatives (e.g., Cordycepin-5’-triphosphate)
IPv6 network supported